Dr. Hartung is a professor at Johns Hopkins Bloomberg School of Public Health and Director of the Johns Hopkins University Center for Alternatives to Animal Testing (CAAT). The main goal of Dr. Hartung’s work is to catalyze a paradigm shift in toxicity testing to improve public health. Due to his background as head of the European Center for the Validation of Alternative Methods of the European Commission (2002-2008), he is involved in the implementation of the 2007 NRC vision document “Toxicity Testing in the 21st Century – a vision and a strategy”. He has furthered the translation of concepts of evidence-based medicine to toxicology (evidence-based toxicology). This aims for systematic assessment of the quality of all tools for regulatory toxicology and the development of new approaches based on annotated pathways of toxicity (the Human Toxome). Dr. Hartung has a broad background in clinical and experimental pharmacology and toxicology documented in more than 450 publications. His previous work centered on the immune recognition of bacteria, including pyrogen testing, and the induced inflammatory response. In experimental and clinical approaches, the pharmacological modulation of these responses was studied. In early 2009, he relocated to the US, and established a laboratory for developmental neurotoxicity research based on genomics and metabolomics.