Huu Tuan Nguyen is a postdoctoral associate in the Mechanobiology laboratory of Professor Robert Kamm at the Massachusetts Institute of Technology. During his doctoral studies at the Ecole Polytechnique Federale de Lausanne-EPFL (Switzerland), he used a variety of microfluidic methods to improve standard breast cancer diagnostic techniques, such as fluorescence in situ hybridization, immunofluorescence, chromogenic in situ hybridization, and antibody microarrays. Furthermore, he discovered a new technique that successfully identifies patients expressing HER2 intratumoral heterogeneity in breast cancer. Since joining Professor Kamm’s lab in May 2018, he has successfully developed a new microfluidic model of cancer research and have performed several assays on the model to answer biological questions concerning early metastasis and nanoparticle-based immunotherapy.
In his presentation, Huu Tuan will discuss tumor-associated macrophages (TAMs) and elements of the tumor microenvironment (TME) that regulate several early cancer metastasis processes, such as hypervascularization. He will present a novel 3D microfluidic model for studying tumors surrounded by stromal cells and extracellular matrix and how he applied this platform to study tumor-induced endothelial cell vascularization and the potential of microfludic devices as tools for personalized medicine that can be used to understand each cancer in their associated TME.